XADAGO is now available in two dosages: 50 mg and 100 mg
The recommended starting dose is 50 mg once daily
XADAGO DOSAGE ADJUSTMENTS1
After 2 weeks, the 50 mg daily dosage may be increased to 100 mg/day on the basis of individual need and tolerability
If a dose is missed, the next dose should be taken at the same time the next day
XADAGO 100 mg/day should be tapered by decreasing the dose to 50 mg/day for one week before stopping
In patients with moderate hepatic impairment, a lower dosage of XADAGO(50 mg/day) should be used. XADAGO is contraindicated in patients with severe hepatic impairment (Child-Pugh C)
Dietary tyramine restriction is not required during treatment with recommended doses of XADAGO. However, patients should be advised to avoid foods containing a very high amount of tyramine because of the potential for severe increases in blood pressure, also referred to as hypertensive urgency, crisis, or emergency.
Can be used with SSRIs at the lowest effective SSRI dose
>87% of patients in clinical trials required no decrease in their levodopa dose2,3
Borgohain R, Szasz J, Stanzione P, et al. Randomized trial of
Safinamide add-on to levodopa in Parkinson’s disease with motor fluctuations.
Mov Disord. 2014;29(2):229-237.
Schapira AHV, Fox SH, Hauser RA, et al. Assessment of safety and efficacy
of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol.