XADAGO RESOURCES AND FREQUENTLY ASKED QUESTIONS1


Learn more about XADAGO by downloading our patient brochure and reviewing answers to frequently asked questions.


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Remember to always follow your healthcare provider's instructions.

XADAGO (safinamide) is a type of prescription medicine known as a monoamine oxidase type B (MAO-B) inhibitor used with levodopa/carbidopa to treat individuals with Parkinson’s disease (PD) who are having off episodes. It is not known if XADAGO is effective to treat PD when taken as a single medicine (monotherapy). It is not known if XADAGO is safe and effective in children.
The recommended starting dose of XADAGO is 50 mg once daily. After 2 weeks, your healthcare provider may decide to increase your dose to 100 mg once daily, if necessary. It is recommended to take XADAGO at the same time each day. Do not start or stop taking XADAGO without talking to your healthcare provider first.
The most common side effects seen with XADAGO are uncontrolled movements (dyskinesia), falls, nausea, and trouble sleeping or falling asleep (insomnia).
No, you do not have to change your diet. Restriction of foods and beverages is usually not required when treated with the recommended doses of XADAGO.
Please talk with your healthcare provider about any changes to your PD medications. XADAGO is intended to be used with levodopa/carbidopa (monotherapy) medications to treat Parkinson’s disease. It is not known if XADAGO is effective to treat PD when taken as a single medicine.
Do not use XADAGO if you are allergic to XADAGO (safinamide), as this can cause swelling of the tongue and mouth and trouble breathing. You should not take XADAGO if you have severe liver disease. Please talk to your healthcare provider if you have concerns about taking XADAGO.
The combination of MAO-B inhibitors like XADAGO and antidepressants has resulted in a serious and sometimes fatal condition called serotonin syndrome.

Do not take XADAGO with opioid medications including meperidine, tramadol, methadone, or propoxyphene, as this could result in serious, sometimes fatal, reactions.

Also, do not take XADAGO with amphetamine, cyclobenzaprine, methylphenidate, or St. John’s wort. Taking these drugs together can also result in serotonin syndrome, which could be fatal.

Do not use XADAGO with dextromethorphan. The combination of MAO inhibitors and dextromethorphan has been reported to cause episodes of psychosis or abnormal behavior.
If a dose of once-daily XADAGO is missed, the next dose should be taken at the same time the next day.
XADAGO should be stored at room temperature, between 68 and 77 degrees, but also allows for temperatures as low as 59 degrees, and as high as 86 degrees.
Call your healthcare provider for medical advice about side effects. You may report side effects by contacting US WorldMeds at 1-888-492-3246 (1-888-4XADAGO). You may also report suspected adverse reactions to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Why XADAGO?

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Reference
  1. XADAGO® (safinamide) [Full Prescribing Information]. Louisville, KY: US WorldMeds, LLC; May 2017.