WHAT IS ON AND OFF TIME?

During a typical day, you experience on and off time1

WHAT IS "GOOD" ON TIME?


"Good" on time is on time when you don't experience TROUBLESOME DYSKINESIA. As you experience diminishing benefits of levodopa/carbidopa over time, it's important to have "good" on time each day.1-3

  • TROUBLESOME DYSKINESIA is when uncontrollable (involuntary), abnormal movements interfere with your daily activities—even during on time4

  • These abnormal movements often occur as a side effect of long-term treatment with levodopa/carbidopa5

  • Examples of dyskinesia include fidgeting, writhing and wriggling, head bobbing, and body swaying6

As you experience diminishing benefits of levodopa/carbidopa over time, it's important to have "good" on time each day

WHAT DOES YOUR DAY WITH PD LOOK LIKE?


Now that you know more about on time and off time, let’s see how well your current PD medication(s) are working for you throughout the day. XADAGO can increase your daily on time without troublesome dyskinesia and can help reduce your off time.7

1

HOW DO YOU FEEL WHEN YOU WAKE UP IN THE MORNING?



2

HOW DO YOU FEEL MID-MORNING?



3

HOW DO YOU FEEL IN THE MIDDLE OF THE DAY?



4

HOW DO YOU FEEL IN THE AFTERNOON?



5

HOW DO YOU FEEL IN THE EARLY EVENING?



6

HOW DO YOU FEEL WHEN YOU GO TO BED?

Here’s what a typical day looks like for you or your loved one with PD.

1

2

3

4

5

6

~0%

Daily Off Time

Talk to your doctor to see if XADAGO can help increase your daily on time without troublesome dyskinesia

NEXT: Why XADAGO?



Pay as little as $25* on your next XADAGO prescription

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*Patients whose prescriptions will be paid for in part or in whole by Medicare, Medicaid, or any similar federal or state healthcare program, are not eligible for savings or rebates according to federal and state law.

The actual savings on your out-of-pocket costs for XADAGO will vary according to refill quantity, personal healthcare insurance coverage, and adherence to FDA dosing guidelines. Please review the XADAGO Prescription Savings Program Terms and Conditions to learn more.
References
  1. Schapira AHV, Fox SH, Hauser RA, et al. Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol. 2017;74(2):216-224.
  2. Borgohain R, Szasz J, Stanzione P, et al. Randomized trial of Safinamide add-on to levodopa in Parkinson’s disease with motor fluctuations. Mov Disord. 2014;29(2):229-237.
  3. Jankovic J. Motor fluctuations and dyskinesias in Parkinson’s disease: clinical manifestations. Mov Disord.2005;20(Suppl 11)S11-S16.
  4. U.S. Department of Health and Human Services, National Institutes of Health, National Institutes of Neurological Disorders and Stroke. Parkinson’s Disease: Hope Through Research. 2014. NIH Publication No. 15-139. Accessed May 8, 2017.
  5. Olanow CW, Stern MB, Sethi K. The scientific and clinical basis for the treatment of Parkinson’s disease. Neurology. 2009;72(Suppl 4)S1-S136
  6. Dyskinesia. The Michael J. Fox Foundation (MJFF) For Parkinson’s Research. Parkinson’s Support Groups. 2017. https://www.michaeljfox.org/understanding-parkinsons/living-with-pd/topic.php?support-groups. Accessed May 8, 2017.
  7. Borgohain R, Szasz J, Stanzione P, et al. Two-Year, Randomized, Controlled Study of Safinamide as Add-on to Levodopa in Mid to Late Parkinson’s Disease. Mov Disord. 2014;29(10):1273-1280.doi: 10.1002/mds.25961.esse