During clinical trials, physicians reported that XADAGO, when added to levodopa/carbidopa, helped control patients’ PD motor symptoms such as1,2*:
More ability to speak
Less shaking (tremor)
More freedom of facial expression
Less stiffness (rigidity)
Less slowed movement (bradykinesia)
Clinical trials showed that once-daily XADAGO can1:
Increase daily on time—without troublesome dyskinesia
Reduce off time and off time symptoms
Help improve your ability to move and take on your day
*As assessed by the Parkinson’s Disease Questionnaire (PDQ-39), a PD-specific health status questionnaire. Results are based on the 100 mg/day dose of XADAGO.
MAO-B is a substance that naturally breaks down chemicals in your brain, like dopamine. Too little dopamine in your brain can cause impaired movement and PD motor symptoms like stiffness (rigidity), freezing, and shaking (tremor).3
XADAGO helps block MAO-B from breaking down dopamine in your brain3
Adding XADAGO to levodopa/carbidopa increases dopamine levels by preserving your body’s dopamine, as well as dopamine made from levodopa, at all stages of PD.
Before taking XADAGO, tell your healthcare provider about all the medications and supplements you are taking.3 While taking XADAGO, discuss with your healthcare provider any medications you may consider starting.3
Most common side effects when taking XADAGO include3:
Uncontrolled, sudden movements (dyskinesia)
Trouble falling asleep or sleeping (insomnia)
Restriction of foods and beverages containing tyramine is usually not required when treated with the recommended doses of XADAGO. However, it is recommended that you avoid foods containing high amounts of tyramine, such as aged cheeses, as some patients may have an increased sensitivity that could lead to an unsafe rise in blood pressure.
All PD patients should be monitored for hallucinations, impulse control, and confusion.