ONCE-DAILY DOSING1

XADAGO is available in two dosages1

  • There are no dietary restrictions at recommended doses of XADAGO
  • Can be used with SSRIs at the lowest effective SSRI dose
  • If a dose is missed, the next dose should be taken at the same time the next day
  • XADAGO 100 mg/day should be tapered by decreasing the dose to 50 mg/day for one week before stopping
  • In patients with moderate hepatic impairment, a lower dosage of XADAGO (50 mg/day) should be used. XADAGO is contraindicated in patients with severe hepatic impairment (Child-Pugh C)

>87% of patients in clinical trials required no decrease in their levodopa dose2,3


XADAGO Clinical Efficacy

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References
  1. XADAGO. Package Insert. US WorldMeds, LLC.
  2. Borgohain R, Szasz J, Stanzione P, et al. Randomized trial of Safinamide add-on to levodopa in Parkinson’s disease with motor fluctuations. Mov Disord. 2014;29(2):229-237.
  3. Schapira AHV, Fox SH, Hauser RA, et al. Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol. 2016;E1-E9.