XADAGO is available in two dosages1

  • There are no dietary restrictions at recommended doses of XADAGO
  • Can be used with SSRIs at the lowest effective SSRI dose
  • If a dose is missed, the next dose should be taken at the same time the next day
  • XADAGO 100 mg/day should be tapered by decreasing the dose to 50 mg/day for one week before stopping
  • In patients with moderate hepatic impairment, a lower dosage of XADAGO (50 mg/day) should be used. XADAGO is contraindicated in patients with severe hepatic impairment (Child-Pugh C)

>87% of patients in clinical trials required no decrease in their levodopa dose2,3

XADAGO Clinical Efficacy

View the data
  1. XADAGO. Package Insert. US WorldMeds, LLC.
  2. Borgohain R, Szasz J, Stanzione P, et al. Randomized trial of Safinamide add-on to levodopa in Parkinson’s disease with motor fluctuations. Mov Disord. 2014;29(2):229-237.
  3. Schapira AHV, Fox SH, Hauser RA, et al. Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol. 2016;E1-E9.