There are no dietary restrictions at recommended doses of XADAGO
Can be used with SSRIs at the lowest effective SSRI dose
If a dose is missed, the next dose should be taken at the same time the next day
XADAGO 100 mg/day should be tapered by decreasing the dose to 50 mg/day for one week before stopping
In patients with moderate hepatic impairment, a lower dosage of XADAGO (50 mg/day) should be used. XADAGO is contraindicated in patients with severe hepatic impairment (Child-Pugh C)
>87% of patients in clinical trials required no decrease in their levodopa dose2,3
Borgohain R, Szasz J, Stanzione P, et al. Randomized trial of
Safinamide add-on to levodopa in Parkinson’s disease with motor fluctuations.
Mov Disord. 2014;29(2):229-237.
Schapira AHV, Fox SH, Hauser RA, et al. Assessment of safety and efficacy
of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol.
2016;E1-E9.
